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Multiple Choice

Which vaccination strategy is recommended for patients with cirrhosis?

In cirrhosis, infection risk is high because immune function is impaired, so vaccination is a key preventive strategy. The best approach combines protection against hepatitis A and B if the patient is not already immune, with pneumococcal vaccination (PCV13 followed by PPSV23) and yearly influenza vaccination, plus other standard vaccines according to guidelines (such as Tdap, MMR, varicella if nonimmune). The idea is to cover the most harmful infections that can worsen liver disease or trigger decompensation. There is no Hepatitis C vaccine, so including one isn’t possible. Giving only the influenza vaccine would leave patients vulnerable to other preventable infections, and skipping vaccination altogether is inappropriate. This comprehensive strategy offers broad protection tailored to the vulnerabilities of cirrhosis.

In cirrhosis, infection risk is high because immune function is impaired, so vaccination is a key preventive strategy. The best approach combines protection against hepatitis A and B if the patient is not already immune, with pneumococcal vaccination (PCV13 followed by PPSV23) and yearly influenza vaccination, plus other standard vaccines according to guidelines (such as Tdap, MMR, varicella if nonimmune). The idea is to cover the most harmful infections that can worsen liver disease or trigger decompensation. There is no Hepatitis C vaccine, so including one isn’t possible. Giving only the influenza vaccine would leave patients vulnerable to other preventable infections, and skipping vaccination altogether is inappropriate. This comprehensive strategy offers broad protection tailored to the vulnerabilities of cirrhosis.