Which statement describes expanded criteria for liver transplantation in HCC beyond Milan criteria?

Prepare for Liver Disease and Tumors Test with tailored flashcards and questions. Get detailed explanations and improve your knowledge. Ace the medical student exam!

Expanded criteria for liver transplantation in hepatocellular carcinoma broaden eligibility beyond the Milan limits by including larger or more numerous tumors if they meet favorable biology after evaluation. A commonly used example is UCSF criteria: a single lesion up to 6.5 cm, or up to three lesions with the largest no more than 4.5 cm and total tumor diameter not exceeding 8 cm. In addition, downstaging strategies use loco-regional therapies to shrink tumor burden to within acceptable limits, followed by multidisciplinary evaluation to assess tumor biology, response, and overall transplant suitability. This combination allows more patients to be considered for transplantation while reserving outcomes similar to those within Milan criteria when criteria are met after downstaging.