Which statement best describes recurrence after liver transplantation?

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Recurrence after liver transplantation means the original liver disease returns in the new graft. This is a real and expected issue for many patients, especially hepatitis C, which almost always reappears in the transplanted liver and can progress to fibrosis or cirrhosis, impacting graft longevity. This concept stands in contrast to other post-transplant problems like graft rejection, infections, or biliary complications, which are different categories of issues: rejection is immune-mediated, infections arise from immunosuppression, and biliary leaks are surgical/structural problems. So, the best description of recurrence is that the original disease can recur in the transplanted liver.