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Multiple Choice

Which serologic marker indicates immunity to HBV?

Immunity to HBV is indicated by anti-HBs, the HBV surface antibody. This antibody develops after successful vaccination or after recovery from a natural HBV infection, signaling protective immunity against future exposure. If someone is vaccinated, you typically see anti-HBs positive with HBsAg negative and anti-HBc negative. If someone has recovered from infection, you’d expect anti-HBs positive along with anti-HBc positive and HBsAg negative. Other markers serve different purposes: HBsAg shows current infection, anti-HBc shows prior exposure, and HBeAg reflects active viral replication and infectivity.

Immunity to HBV is indicated by anti-HBs, the HBV surface antibody. This antibody develops after successful vaccination or after recovery from a natural HBV infection, signaling protective immunity against future exposure. If someone is vaccinated, you typically see anti-HBs positive with HBsAg negative and anti-HBc negative. If someone has recovered from infection, you’d expect anti-HBs positive along with anti-HBc positive and HBsAg negative. Other markers serve different purposes: HBsAg shows current infection, anti-HBc shows prior exposure, and HBeAg reflects active viral replication and infectivity.