Which patient demographic is at increased risk for hepatic adenoma?

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Estrogen exposure promotes the development and growth of hepatic adenomas. The strongest and most classic association is with exogenous estrogen in reproductive-age women, particularly those using oral contraceptives. In this group, estrogen stimulates hepatocyte proliferation, leading to adenoma formation; removing the estrogen often leads to regression or slowing of growth. Other scenarios—elderly men with cirrhosis or children with biliary atresia—are not typical risk factors for hepatic adenoma and are more linked to other liver conditions (cirrhosis-related nodules or congenital biliary disease, respectively). So, the patient demographic at increased risk is young women using oral contraceptives.