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Multiple Choice

Which of the following features is typical of autoimmune hepatitis?

Autoimmune hepatitis is classically seen in young to middle-aged women and shows a hepatocellular injury pattern with markedly elevated transaminases. Key clues are positive autoantibodies such as ANA or ASMA, hypergammaglobulinemia (especially elevated IgG), and a strong response to corticosteroids. A liver biopsy often reveals interface hepatitis (piecemeal necrosis at the portal–lobular interface) with a lymphoplasmacytic infiltrate. This combination—female predominance, hepatocellular enzyme elevation, autoantibodies, high IgG, steroid responsiveness, and interface hepatitis on biopsy—best fits autoimmune hepatitis. The other descriptions don’t match this pattern: one option emphasizes male predominance, another describes low transaminases and negative autoantibodies with antifungal therapy, and another focuses on children with a cholestatic picture (high ALP) and no biopsy requirement.

Autoimmune hepatitis is classically seen in young to middle-aged women and shows a hepatocellular injury pattern with markedly elevated transaminases. Key clues are positive autoantibodies such as ANA or ASMA, hypergammaglobulinemia (especially elevated IgG), and a strong response to corticosteroids. A liver biopsy often reveals interface hepatitis (piecemeal necrosis at the portal–lobular interface) with a lymphoplasmacytic infiltrate. This combination—female predominance, hepatocellular enzyme elevation, autoantibodies, high IgG, steroid responsiveness, and interface hepatitis on biopsy—best fits autoimmune hepatitis. The other descriptions don’t match this pattern: one option emphasizes male predominance, another describes low transaminases and negative autoantibodies with antifungal therapy, and another focuses on children with a cholestatic picture (high ALP) and no biopsy requirement.