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Multiple Choice

Which combination of features is typical of Wilson disease involvement of the liver?

Wilson disease involves impaired copper transport in the liver, leading to copper buildup and systemic copper overload. This typically shows low serum ceruloplasmin because the protein is produced in the liver and requires proper copper loading; the excess copper is then excreted in urine, giving elevated urinary copper. Copper deposition also affects the eye, producing Kayser-Fleischer rings in the cornea. Taken together, the combination of low ceruloplasmin, Kayser-Fleischer rings, and elevated urinary copper is the classic pattern seen with liver involvement in Wilson disease.

Wilson disease involves impaired copper transport in the liver, leading to copper buildup and systemic copper overload. This typically shows low serum ceruloplasmin because the protein is produced in the liver and requires proper copper loading; the excess copper is then excreted in urine, giving elevated urinary copper. Copper deposition also affects the eye, producing Kayser-Fleischer rings in the cornea. Taken together, the combination of low ceruloplasmin, Kayser-Fleischer rings, and elevated urinary copper is the classic pattern seen with liver involvement in Wilson disease.