Which autoantibodies are commonly positive in autoimmune hepatitis?

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Multiple Choice

Which autoantibodies are commonly positive in autoimmune hepatitis?

Autoimmune hepatitis most often shows antibodies directed against components of hepatocytes, with the classic pattern being antinuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA). This combination is especially characteristic of the common form, autoimmune hepatitis type 1, and supports the diagnosis when aligned with clinical features and liver biopsy findings. Anti-LKM1 and other antibodies are more typical of autoimmune hepatitis type 2, while anti-mitochondrial antibodies point to primary biliary cholangitis. Rheumatoid factor or anti-CCP relate to rheumatoid arthritis, and HBsAg/anti-HCV are viral markers. So ANA and ASMA are the best-supported serologic pattern for autoimmune hepatitis.

Autoimmune hepatitis most often shows antibodies directed against components of hepatocytes, with the classic pattern being antinuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA). This combination is especially characteristic of the common form, autoimmune hepatitis type 1, and supports the diagnosis when aligned with clinical features and liver biopsy findings. Anti-LKM1 and other antibodies are more typical of autoimmune hepatitis type 2, while anti-mitochondrial antibodies point to primary biliary cholangitis. Rheumatoid factor or anti-CCP relate to rheumatoid arthritis, and HBsAg/anti-HCV are viral markers. So ANA and ASMA are the best-supported serologic pattern for autoimmune hepatitis.

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