LI-RADS and biopsy guidelines for HCC diagnosis in noncirrhotic livers.

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LI-RADS and biopsy guidelines for HCC diagnosis in noncirrhotic livers.

In noncirrhotic livers, imaging alone is often not enough to confirm hepatocellular carcinoma. LI-RADS standardizes how liver lesions are described on imaging, but its high-probability categories (which can be diagnostic in cirrhotic or otherwise high-risk patients) are less definitive in noncirrhotic livers because benign nodules and other cancers can mimic HCC. When the imaging features are not unequivocally diagnostic for HCC, tissue confirmation through biopsy is commonly needed to establish the diagnosis. Serum AFP by itself is not reliable enough to diagnose HCC, especially in the noncirrhotic setting.

In noncirrhotic livers, imaging alone is often not enough to confirm hepatocellular carcinoma. LI-RADS standardizes how liver lesions are described on imaging, but its high-probability categories (which can be diagnostic in cirrhotic or otherwise high-risk patients) are less definitive in noncirrhotic livers because benign nodules and other cancers can mimic HCC. When the imaging features are not unequivocally diagnostic for HCC, tissue confirmation through biopsy is commonly needed to establish the diagnosis. Serum AFP by itself is not reliable enough to diagnose HCC, especially in the noncirrhotic setting.

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