According to Milan criteria, liver transplantation for HCC is considered when:

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Multiple Choice

According to Milan criteria, liver transplantation for HCC is considered when:

Milan criteria assess which hepatocellular carcinoma cases are likely to have good outcomes after liver transplantation by limiting tumor burden and excluding spread. The best-fit rule is a single tumor no larger than 5 cm, or up to three tumors each no larger than 3 cm, with no gross vascular invasion or extrahepatic disease. This combination of size, number, and lack of vascular invasion correlates with acceptable post-transplant survival. Other scenarios don’t fit because they either ignore these tumor-burden limits or rely on factors not part of the criteria. For example, having portal hypertension with any number of nodules doesn’t align with the specified size/number thresholds and doesn’t address vascular invasion. Requiring non-cirrhotic liver disease isn’t a Milan stipulation, since transplantation eligibility in HCC often involves cirrhotic livers as well. Finally, lesions larger than the allowed size, such as those over 8 cm, exceed the Milan limits even if technically resectable.

Milan criteria assess which hepatocellular carcinoma cases are likely to have good outcomes after liver transplantation by limiting tumor burden and excluding spread. The best-fit rule is a single tumor no larger than 5 cm, or up to three tumors each no larger than 3 cm, with no gross vascular invasion or extrahepatic disease. This combination of size, number, and lack of vascular invasion correlates with acceptable post-transplant survival.

Other scenarios don’t fit because they either ignore these tumor-burden limits or rely on factors not part of the criteria. For example, having portal hypertension with any number of nodules doesn’t align with the specified size/number thresholds and doesn’t address vascular invasion. Requiring non-cirrhotic liver disease isn’t a Milan stipulation, since transplantation eligibility in HCC often involves cirrhotic livers as well. Finally, lesions larger than the allowed size, such as those over 8 cm, exceed the Milan limits even if technically resectable.

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